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Coarctation in the Marfan Syndrome

Arch Intern Med. 1964;113(3):342-349. doi:10.1001/archinte.1964.00280090028005.
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The Marfan syndrome is now recognized as a heritable disorder of connective tissue that usually follows a simple mendelian dominant pattern of Transmission.1 Manifestations of the abnormality are quite variable but are seen most often in the cardiovascular, musculoskeletal, and ocular systems. Coarctation of the aorta is not one of the common findings in the Marfan syndrome, but it is encountered more often than expected on a chance basis.1 This paper consists of a case report of a patient having this association and a review of the pertinent literature. In addition, the patient's pedigree is presented and several suggestions are made for advising and treating affected relatives.

Report of Case  A 41-year-old construction electrician was referred to the Dallas Veterans Administration Hospital on Dec 20, 1960, for evaluation of weakness and dyspnea. His early growth had been rapid, and before age 15 he was six feet (182.9 cm)


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