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Thyroid Cancer in Adult Following External Irradiation

Arch Intern Med. 1964;113(1):97-100. doi:10.1001/archinte.1964.00280070099016.
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Thyroid carcinoma has been observed in a significant number of children and adolescents who received x-ray therapy to the thymus in infancy and early childhood.1-7 A less significant number of adults developing thyroid carcinomas after irradiation have been reported.7-11 In a survey of 70 radiologists and 31 thyroid specialists in 1949, Quimby and Werner12 reported that none had ever seen thyroid carcinoma develop in a normal thyroid gland when that region had been in the field of x-ray for another condition.

The purpose of this paper is to report a case of thyroid carcinoma in an adult male who received external x-ray to the neck at eight years of age for "Hodgkin's disease." His thyroid gland at the time of x-ray therapy was clinically normal and remained so for 13 years before enlargement was noted. Enlargement initially occurred on the side of his neck exposed to the


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