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Tetanus Prophylaxis and Therapy.

William K. Hamilton, MD
Arch Intern Med. 1963;112(5):805. doi:10.1001/archinte.1963.03860050192049.
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This work is a thorough discussion of prophylaxis against tetanus and an outline of general principles of treatment of clinical tetanus.

It has been the concern of some people involved in care of tetanus patients for some years that too much emphasis has been placed upon the role of passive immunization in any program of prophylaxis or treatment of tetanus. It is gratifying to those having this prejudice to find such a thorough coverage of problems of prophylaxis and immunization. Misconceptions which exist concerning the efficacy of tetanus antitoxin, disadvantages of serum therapy, and medicolegal implications of using or omitting this form of therapy are discussed. Perhaps the author's feeling concerning the problem is best summarized by his statement—"in light of the questionable value of the serum treatment, its omission cannot be condemned." A thorough experimental study is reported which evaluates antigen-antibody responses when serum and toxoid are administered simultaneously.


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