0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Clotting Mechanism in Endotoxin Shock

COL ROBERT M. HARDAWAY, MC; CAPT DALE JOHNSON, MC
Arch Intern Med. 1963;112(5):775-782. doi:10.1001/archinte.1963.03860050162020.
Text Size: A A A
Published online

If one injects bovine thrombin intraaortically into dogs, a number of changes take 1-3 place. There is a precipitous fall in the aortic blood pressure which gradually returns to relatively normal levels over a 15to 30-minute period. This is, under proper circumstances, only temporary, and a secondary fall soon begins which terminates fatally within 12 to 24 hours. Autopsy regularly shows a hemorrhagic necrosis of the gastrointestinal mucosa which is typical of canine shock. Blood coagulation changes are interpreted as indicative of an episode of intravascular coagulation. There is a rapid and dramatic fall in level of blood fibrinogen which is marked within 20 minutes but returns to normal or supranormal levels within four to six hours. There is a marked but temporary fall in platelets. Prothrombin time is prolonged. These changes are probably caused by the using up of the blood coagulation factors in an intravascular clotting episode. In

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 75

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();