The Macula Densa and Juxtaglomerular Body in Cirrhosis

Arch Intern Med. 1963;112(5):708-715. doi:10.1001/archinte.1963.03860050095010.
Text Size: A A A
Published online

Introduction  Patients with cirrhosis frequently have impaired water and sodium excretion. Hyponatremia, ascites, and edema are often present, and renal failure may occur terminally.1,2 No renal pathology has been found to account for these abnormalities. However, the juxtaglomerular bodies and the maculae densae in the kidney have not been investigated in these patients. These renal structures are probably associated with the regulation of water and sodium balance. The juxtaglomerular body is a small group of epithelioid cells that lie in the media of the afferent arteriole near each renal glomerulus (Fig 1). An increase in the granularity and the number of the juxtaglomerular cells has been associated with changes in water and sodium balance, and it is thought that the cells are responsible for the production of renin.3 A study of the juxtaglomerular bodies in patients with cirrhosis was therefore undertaken.Adjacent to the juxtaglomerular body is the


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 21

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.