We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Hyperglycemic Hyponatremia in Nondiabetic Patients

Arch Intern Med. 1963;112(3):344-346. doi:10.1001/archinte.1963.03860030098008.
Text Size: A A A
Published online


Physicians managing patients under hypothermia or after major operations, particularly cardiac procedures, will observe with increasing frequency an acute, seemingly paradoxical hyponatremia. The low serum sodium concentration develops abruptly, apparently out of proportion to the amount of fluid recently administered, and without producing any of the symptoms of water intoxication which might be expected to accompany such rapid dilution of electrolytes. As the underlying mechanism of this deceptive hyponatremia often is not appreciated, incorrect diagnosis and potentially harmful therapy may follow its discovery. A discussion of the problem therefore seems warranted.

Report of Cases  Typically, this type of hyponatremia has been discovered after 24 hours of therapeutic hypothermia or on the day following major surgery. On routine determination, a previously normal serum sodium concentration unexpectedly has been found below 120 mEq/liter in asymptomatic patients, as demonstrated in the following cases:

Case 1.  —A 13-year-old girl aspirated secretions 36 hours after


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

13 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.