We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Penicillin N Therapy of Enteric Bacillary Infections

Arch Intern Med. 1963;111(6):799-808. doi:10.1001/archinte.1963.03620300119019.
Text Size: A A A
Published online

Since the introduction of antibacterial agents, serious infections due to enteric pathogens have occurred with increasing frequency.1 Because these microorganisms are quite often resistant to the commonly employed, safe antibacterial agents, therapy frequently requires the use of agents with significant potential for serious human toxicity. Specifically, the treatment of infections due to Salmonella species other than Salmonella typhosa are frequently not cured with chloramphenicol2; Proteus mirabilis is resistant to the clinically usable concentrations of most antibiotics with the exception that large doses of penicillin G may be effective in some circumstances.3 Recently, Noall et al4 emphasized the difficulty in attaining success in treatment of Proteus infections.

Approximately ten years ago the antibiotic penicillin N (cephalosporin N) was isolated and identified as D-4-amino-4-carboxy-n-butyl penicillin. When compared with penicillin G (benzyl penicillin), this penicillin was not very active as an inhibitor of Gram-positive microorganisms. However, it was surprisingly


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 10

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.