Cryptococcosis, a systemic fungus infection caused by Cryptococcus neoformans, most commonly involves the central nervous system,1 lungs,2 skin,3 and bones.4 Almost every tissue can be affected when the fungus is disseminated; however, only occasionally are such infections clinically significant. In rare instances, involvement of adrenal glands,5,6 cardiovascular system, gastrointestinal tract, or genitourinary system may lead to organ dysfunction or failure.1
Histologic evidence of hepatic involvement in disseminated cryptococcosis has been previously reported7-10; however, in these instances there was no evidence that intrahepatic fungal proliferation had interfered with liver function.
The present paper is a report of two patients in whom hepatic failure was most likely caused by intrahepatic cryptococcosis. One patient, with Hodgkin's disease and disseminated cryptococcosis, developed hepatic failure as the terminal event in her illness. Microscopic examination disclosed hepatic necrosis associated with cryptococcosis without evidence of other liver disease. The second
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 33
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.