In 1958, Åström, Mancall, and Richardson described a demyelinating disease distinct from multiple sclerosis and other demyelinating disorders which they called progressive multifocal leukoencephalopathy.1 The condition is characterized by progressive and fatal neurologic deterioration with "dementia, alterations in the state of consciousness, language disorders, visual impairment and evidence of pyramidal tract involvement."1 Pathologically, the brain shows widespread focal destruction of myelin sheaths in all gradations of size and states of evolution with relative sparing of the axis cylinders. "These foci have shown a pronounced tendency to become confluent so that large plaquelike lesions may occur. Associated with the myelin destruction is a distinctive cytological reaction consisting of hypertrophy of astrocytes into bizarre gigantic forms and alteration of oligodendrocytes with the production of large, round, densely basophilic nuclei."1 Recently, Richardson reviewed the subject and accepted a total of 24 cases as progressive multi focal leukoencephalopathy. The additional material
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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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