Jaundice is not an uncommon symptom in patients with Hodgkin's disease, but its specific etiology is often difficult to establish. This study was undertaken in an effort to clarify the pathogenesis of jaundice in patients with Hodgkin's disease. In particular intrahepatic cholestasis with a picture of complete obstruction of the common duct presents a real diagnostic and therapeutic problem. Two additional cases of intrahepatic cholestasis secondary to Hodgkin's disease are reported.
The incidence of jaundice in Hodgkin's disease as reported in the medical literature is between 3% and 68%.1-9
Material and Methods
The present series consists of a study of 615 patients with confirmed diagnosis of Hodgkin's disease by biopsy. These patients were seen at the Ohio State University Hospital between June, 1949, and June, 1959.
Of the 615 patients with Hodgkin's disease, 83 developed one or more episodes of jaundice during the course of their illness, an
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 61
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.