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October 1962, Vol 110, No. 4 >
ARTICLE | October 1962

Circulating Factor VIII Anticoagulant in Bullous Dermatitis

JEREMY V. COOKE, M.D.; JOHN B. ANDERSON, B.A.; WILLARD S. GAMBLE, M.D.
Arch Intern Med. 1962;110(4):511-515. doi:10.1001/archinte.1962.03620220103016.
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A circulating anticoagulant as the cause of a prolonged clotting time was described in 1906 by Weil.1 An excellent review of this subject has recently appeared in which anticoagulants against Factors I, V, VII, VIII, IX, XI, and XII have been defined.2 They have been reported in a variety of diseases including systemic lupus erythematosus, dysproteinemias, liver disease, and penicillin and transfusion reactions as well as generalized skin diseases. Two cases of dermatitis herpetiformis3,4 and 2 cases of pemphigus vulgaris5,6 were found to have an anticoagulant against an unspecified factor in the first stage of clotting. A fifth case of a vesiculobullous eruption7 was found to have an anticoagulant against tissue thromboplastin. We wish to report a case of generalized bullous dermatitis associated with an anticoagulant against Factor VIII (antihemophilic globulin). We are unaware of any previous case report of a specific anticoagulant against Factor

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