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Peripheral Neuropathy in Bronchogenic Carcinoma

Arch Intern Med. 1962;110(4):461-466. doi:10.1001/archinte.1962.03620220053009.
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Introduction  Bronchogenic carcinoma has been associated with a variety of extrapulmonary abnormalities that are unrelated to metastatic spread of the neoplasm. These have been classified as metabolic, neuromuscular, connective tissue and osseous, vascular, and hematologic.1 It is the purpose of this paper to report the occurrence of peripheral neuropathy in a patient with bronchogenic carcinoma and to review the recorded peripheral neurologic syndromes which occur in neoplastic diseases in the absence of metastasis to the central nervous system.

Report of a Case  A 64-year-old white male was admitted to the Georgetown Medical Division of the District of Columbia General Hospital for the first time in September, 1961, because of weakness and weight loss of 1 month's duration.One month prior to admission he noted the gradual onset of a mild cough, productive of whitish sputum, anorexia, progressive weakness, and a 30 lb. weight loss. Ankle edema was noted shortly


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