This is an excellent manuscript, dealing with the complexity of a disease syndrome in logical, lucid fashion. The reader, on reaching the final chapter still confused, is bewildered by the protean aspects of the thalassemias themselves, not by the presentation of the subject matter. Introducing the chapter on the heterogeneity of the thalassemia variants, Bannerman's sentence "Since this problem is under active investigation, it is difficult to give a satisfactory account of it at present" applies equally well to porphyrin and iron metabolism or to the possible role of globin defects still unrecognized. Yet the author clears the hurdle with room to spare on each major subject. A casual reader may be discouraged by the complexity of certain discussions, but one with a passing knowledge of the thalassemias will appreciate every paragraph.
Perhaps the publisher did not clear his hurdle as well. Should this manuscript be found as a monograph,
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