Myoglobinuria and Hypokalemia in Regional Enteritis

Arch Intern Med. 1962;110(1):117-124. doi:10.1001/archinte.1962.03620190119019.
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The occurrence of gross myoglobinuria in man is unusual though it has been reported in a number of circumstances. Most instances have involved either muscle injury or an undefined state in which there is recurrent myoglobinuria often after exercise. In the case to be reported here, myoglobinuria occurred in a setting of metabolic abnormalities induced by regional enteritis and its treatment with cortisone. The clinical and laboratory data suggest that exercise of muscles weakened by potassium and other deficiencies was the cause of the myoglobinuria.

Report of a Case  A 47-year-old civil engineer was referred to the Pratt Clinic on Oct. 22, 1953, for evaluation of regional enteritis. Six years previously, he had begun to have persistent abdominal pain and aching in various joints. One year later, in 1948, at a celiotomy, 20 cm. of the terminal ileum and the ileocecal valve were found to be indurated and inflamed. The


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