During the past several decades evidence has accumulated which strongly implies that elevated levels of serum total cholesterol are frequently associated with increased manifestations of atherosclerosis.1,2 If such a relationship is real it is important to learn means for lowering elevated cholesterol levels. Before such control can be convincingly achieved, however, much more must be learned about the natural variability of cholesterol levels under the influence of the normal vicissitudes of life.
The patient whose history, physical findings, and laboratory data are presented here was followed for 12 years through intermittent illnesses with unpredictable and erratic changes in level of serum cholesterol.
Report of a Case
The patient was a 56-year-old lawyer of Anglo-Saxon descent. He had practiced his profession in reasonably good health for 30 years until he was first admitted to Vanderbilt University Hospital on Sept. 24, 1946, with mild, right-sided weakness and dysphasia. This had come