Among the striking manifestations of nephrosis or nephrotic syndrome are hyperlipidemia and lipemia, which are reflections of increased levels of certain classes of serum lipoproteins. Selected studies on the character and mechanisms of the hyperlipoproteinemia are summarized in this article. The physiologic and morphologic effects of the lipoprotein abnormality have been omitted from consideration, for lack of relevant data of a definitive nature. Recent observations in man are emphasized when available, but studies on the experimental disease in rats and dogs are also included. Normal serum lipoprotein classes and normal lipoprotein metabolism are described briefly as a background for the abnormal findings in nephrosis. Despite the continued interest of clinicians and physiologists and more recently chemists in the lipid derangement in nephrosis, very few questions concerning its origin can be considered settled.
State of Serum Lipids and Lipoproteins
Serum lipids under normal and pathologic conditions exist largely in combination with