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Antibiotics and Gamma-Globulin in Pseudomonas Infections

Arch Intern Med. 1962;109(6):712-716. doi:10.1001/archinte.1962.03620180074008.
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Systemic infections due to Pseudomonas aeruginosa appear to be a problem in patients who have had open heart surgery, extensive burns, severe pyelonephritis, and previous intensive chemotherapy.1-5 It is for this reason that the following cases which responded to vigorous therapy with a combination of agents given by the intravenous route are being presented. If the presumptive diagnosis of acute bacterial endocarditis in one of the patients is correct, it is only the third of the reported cases due to this organism to have survived.1,6-8 Similarly, the case of necrotizing papillitis due to Pseudomonas aeruginosa may be the first to have survived this disease.4

Therapy in each case was based on 2 findings previously reported from this laboratory and by others. The first was potentiation between polymyxin B and oxytetracycline against Ps. aeruginosa, and the second was the potentiation of antibiotics by the addition of relatively large


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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