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Arch Intern Med. 1962;109(4):502. doi:10.1001/archinte.1962.03620160128033.
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National Blood Serum Cholesterol Survey to be Conducted by the College of American Pathologists.—  The measurement of serum cholesterol as presently practiced is admittedly unsatisfactory because of wide variations in results. This variability is attributable to the use of diverse methods, and to the unavailability of an acceptable universal standard.The estimation of serum cholesterol, long used in the study of diabetes, nephritis, and disorders of the liver, has become of added importance in recent years because of the relation of cholesterol metabolism to atherosclerosis and heart disease. The need for a procedure which will give reproducible results from place to place and from year to year is imperative.It is the purpose of the Standards Committee of the College of American Pathologists to characterize a best cholesterol standard for universal use, and to recommend an analytical procedure which may serve as a consistent point of reference.This national


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