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ARTICLE |

Adrenergic Mechanisms

Robert M. Dowben, M.D.
Arch Intern Med. 1962;109(2):247. doi:10.1001/archinte.1962.03620140119019.
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ABSTRACT

Adrenergic mechanisms are of widespread importance in the regulation of function and reaction to stimulus of many body organs. Although our knowledge of these mechanisms is still very fragmentary, the area has been the subject of intense investigative interest and progress during the last few years. This report of a Ciba Symposium is a welcome means for the casual observer to become au courant with the most recent observations and theories in this field.

The symposium begins with a discussion of the biosynthesis, metabolic degradation, and storage of the catechol amines. Some excellent discussions concerning our present understanding of the mechanism of action of bretylium, guanethidine, and other adrenergic inhibitors and blocking agents follow. Of particular interest is a review of the recently elucidated mechanism of adrenalin action on carbohydrate metabolism involving the increased formation of cyclic adenylic acid and the activation of phosphorylase by Professors Sutherland and Lundholm. The

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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