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November 1961, Vol 108, No. 5 >
ARTICLE | November 1961

Tuberous Sclerosis in the Adult:  An Unusual Case Without Mental Deficiency or Epilepsy

ROBERT LEE SCHEIG, M.D.; PAUL BORNSTEIN, M.D.
Arch Intern Med. 1961;108(5):789-795. doi:10.1001/archinte.1961.03620110129017.
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The signs and symptoms of tuberous sclerosis usually appear in infancy or early childhood with no orderly sequence of development.1 Seizures and mental deficiency may be apparent at the age of 1 or 2 years while adenoma sebaceum and other cutaneous lesions most commonly appear between the ages of 4 and 9. Sometimes patients may show a forme fruste of the disease in which some of the features are absent. The disease, which affects males more commonly than females, occurs in approximately 1:50,000 births.2 About half give a family history of mental retardation, seizures, severe psychopathic or psychotic tendencies, or characteristic skin lesions.1 Inheritance appears to be on the basis of a rare autosomal dominant gene with incomplete penetrance.3,4 Occasionally, the gene may appear as a mutant. Formes frustes are thought to be due to an independent pair of modifying genes. Although 30% of patients are

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

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Compression-Only CPR: Pushing the Science Forward
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AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
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