We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Observations on Digitalis Intoxication

Arch Intern Med. 1961;108(2):171-188. doi:10.1001/archinte.1961.03620080003002.
Text Size: A A A
Published online

Since Withering's oft-quoted observations on digitalis intoxication much has been written. While the exact frequency of cardiotoxicity has not been determined, the increasing number of case reports appearing in the literature suggest that this complication of digitalis therapy is of sufficient magnitude to demand repeated, careful examination of all digitalized patients, and, perhaps, even to question the need for continued use of the drug.

Many previous studies on digitalis intoxication have been retrospective.1-9 Whereas much valuable information has resulted from this approach, such reports have many and obvious shortcomings.10

In two planned studies11,12 the incidence of digitalis toxicity was considerably higher than might have been suspected from less well-designed observations. Because of this, we have studied all patients developing digitalis intoxication in our hospital on a day-to-day basis for a 12-month period (July 1, 1958, to June 30, 1959).

Methods and Materials  The Veterans Administration Hospital in


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

102 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.