0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Cirrhosis of the Liver and Decreased Arterial Oxygen Saturation

WALTER H. ABELMANN, M.D.; GERTRUDE E. KRAMER, M.D.; JEAN M. VERSTRAETEN, M.D.; MICHAEL A. GRAVALLESE JR., M.D.; WILLIAM F. McNEELY, M.D.
Arch Intern Med. 1961;108(1):34-40. doi:10.1001/archinte.1961.03620070036005.
Text Size: A A A
Published online

Unsaturation of arterial blood for oxygen in patients with cirrhosis of the liver was first reported by Snell in 1935.1 In a later study Keys and Snell2 presented evidence for a shift of the hemoglobin dissociation curve of whole blood to the right and a decreased affinity of hemoglobin for oxygen in such patients. They concluded that this accounted for the abnormally low saturation. It is the purpose of the present communication to present evidence for an alternate explanation of unsaturation of arterial blood in patients with cirrhosis of the liver.

Arterial unsaturation is usually produced either by a reduced diffusing capacity of the lungs or by increased venous admixture. The latter includes true anatomic venous admixture from intracardiac or extracardiac right-to-left shunts, as well as physiologic venous admixture due to perfusion of alveoli, which are poorly or not at all ventilated. Before the hypothesis of Keys and

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 30

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();