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Bleeding Syndromes: A Clinical Manual

Virginia H. Donaldson, M.D.
Arch Intern Med. 1961;107(6):955. doi:10.1001/archinte.1961.03620060155023.
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This is an unusually complete and enlightened discussion of hemorrhagic states in terms which will really help the practicing physician in his understanding and treatment of these problems.

Emphasis is placed on bleeding states associated with hereditary deficiencies of clotting factors and includes such recently described coagulation defects as plasma thromboplastin antecedent deficiency and Hageman trait. Hageman trait is of special interest in that it is characterized by lack of a clotting activity easily demonstrated in the laboratory, but is unassociated with a bleeding tendency. In all these conditions the patterns of inheritance are reviewed together with the problems of daily living which face a family fated to one of these conditions. The thrombocytopenias are considered very logically. Discussion extends to such conditions as scurvy, purpura with dysproteinemia, autoerythrocyte sensitization, and also the hemorrhagic complications of extracorporeal circulation.

Items of importance in making a clinical diagnosis are covered, which include


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