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Malignant Lymphoma, Plasmacytosis, Dysproteinemia

JOHN H. PETERS, M.D.; PAUL HELLER, M.D.; JONAS VALAITIS, M.D.
Arch Intern Med. 1961;107(6):903-907. doi:10.1001/archinte.1961.03620060103012.
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Abnormal serum proteins have been occasionally detected in patients with malignant lymphoma.1-3 The "myeloma-type" electrophoretic characteristics of these proteins have given rise to the thought of a possible nosologic relationship between lymphoma and myeloma.1 The fact that ultracentrifugal analysis has revealed the presence of macroglobulins in some of the cases4 has not detracted from the possibility of this relationship and has broadened the spectrum of diseases with dysproteinemia. The following report deals with an additional patient with lymphoma and dysproteinemia. It is of particular interest that during the course of observation of this patient the character of the hyperglobulinemia changed: The initially present broad gamma peak in the electrophoretogram was replaced by a "myeloma-type" globulin within a few weeks.

A 41-year-old Negro male maintenance worker had been quite well except for occasional dyspepsia until 6 months prior to admission when he began to notice easy fatigability and

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