This symposium is an excellent summary of the progress that has been made in the fractionation, isolation, and at least partial chemical analysis of the various hormones of the human anterior pituitary. Growth hormone from human and monkey pituitaries has a lower molecular weight than that from beef, sheep, or pig pituitaries, and the terminal amino acid sequences vary from species to species. These molecular differences offer a basis for the previously observed differences in biologic activity and their apparent immunologic differences. The use of human growth hormone (HGH) has made it possible to study its influence on fatty acid, protein, and carbohydrate metabolism in patients.
Clinically gonadotrophic hormones from human pituitaries appear to be more effective than those from beef and sheep. Chemical characterization has not proceeded as far as with the growth hormone, probably because there is no general agreement on specific assays for FSH or ICSH. Until