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ARTICLE |

The Chemistry of Thyroid Disease

Elmer L. DeGowin, M.D.
Arch Intern Med. 1961;107(3):464. doi:10.1001/archinte.1961.03620030152027.
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ABSTRACT

Modern diagnosis and treatment of thyroid diseases is utterly dependent upon a working knowledge of the chemistry of the thyroid hormones. Without such background the clinician cannot interpret the results of the newer functional tests, such as the level of protein-bound iodine in the blood serum or the thyroidal uptake of I131. Recent investigations have yielded the discovery of several causes for myxedema, delineated by tests stimulating the anterior pituitary or blocking various enzyme systems that participate in the synthesis of thyroxine. The physician will therefore welcome this well-ordered succinct presentation of present chemical knowledge, culled by experts in the field from the enormous and confusing literature on the subject.

The authors carefully selected for detailed discussion what they consider the best and most important work, avoiding ponderous review of many articles which seem, at present, to be unimportant. The result is 65 pages of text that telly a

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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