0
ARTICLE |

The Danger of Corticotropin in Addison's Disease

DANIEL B. STONE, M.B. (LOND.); JUDITH G. JEWEL, M.D.
Arch Intern Med. 1961;107(3):372-374. doi:10.1001/archinte.1961.03620030060007.
Text Size: A A A
Published online

Despite the fact that Thorn and his associates1 have given several thousand infusions of corticotropin (ACTH) to patients with a great variety of disease, they observed untoward reactions in 6 patients only. Five of these had Addison's disease. Our experience is much less extensive. In our hospital from 1950 through 1958, medical residents gave corticotropin diagnostically to 17 patients suspected of having adrenocortical insufficiency. The patients did not receive 9-α-fluorohydrocortisone. Two of the 17 died under circumstances which we believe must be attributed to the use of corticotropin.

Report upon Patients  A 65-year-old man with generalized blastomycosis appeared chronically but not seriously ill. There was weakness, anorexia, nausea, slight pigmentation, and hypotension. He was given 20 units of corticotropin gel intramuscularly for 2 days. It was thought that the collection of urine had been incomplete, so the test was recommended one day later. Eight hours after the fourth dose

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();