Perhaps no other single mode of therapy is applied with such empiricism and as illogically as the administration of hemostatic agents. This criticism does not apply to the administration of specific therapy where the diagnosis has been established, such as the use of antihemophilic globulin in a patient with hemophilia. Rather, it is directed to the inappropriate use of an ever-increasing number of hemostatic agents some of which would seem to have little chance of providing significant benefit to the patient.
It is understandable that the physician faced with the problem of severe hemorrhage of unexplained etiology is going to resort to any therapeutic measure that may be beneficial no matter how empirical the approach. Unfortunately, and at times inexcusably, this approach to therapy often precedes an adequate appraisal of the hemostatic mechanism in the bleeding patient. In many respects this train of events is "a sign of the times"
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 1
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.