Biochemistry of Blood in Health and Disease.

Raymond F. Sheets, M.D.
Arch Intern Med. 1960;106(6):905-906. doi:10.1001/archinte.1960.03820060157036.
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The missile men of the space age have described the time from the blueprint stage of a weapon until it can be used effectively as lead time. Lead times of four, three, or even two years upset the missile men, especially when the delay is due to lack of money. In medicine, lead time may be defined as the time elapsing after a piece of basic information is recorded until it is used in the diagnosis and treatment of disease in human beings. Lead times in medicine are often many times longer than four years because there are so few physicians who are able to take basic information and apply it to the treatment of the patient for the first time. After someone has shown the way initially many physicians are capable of using the knowledge. I believe an outstanding need in medicine today is to shorten the lead time


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