Research continues on several "biophysical" parameters which can influence the survival of the human red cell under conditions of blood-bank storage, for example, the type of container, above-freezing temperature, buffer, pH, anticoagulants, dehydrants, etc. While supplying worthwhile information for improvement in the art of blood-banking, these approaches do not at the present appear destined to yield any major extension of red cell life.
Another biophysical approach, the complete suspension of degradative changes by deep freeze, has led to recent notable advances. There is now no question that red cells can be stored at —80 C or below in the presence of glycerol for months or even years, and be thawed under appropriate conditions to give an essentially normal post-transfusion lifespan. Rapid progress is being made in the development of techniques for processing the frozen red cells, particularly through the combined efforts of the Protein Foundation in Boston and the Chelsea
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 9
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.