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ARTICLE |

Hemangiomatous Hemihypertrophy of Bone

ALBERT N. BREST, M.D.; ALEX E. PEARCE, M.D.; WILLIAM LIKOFF, M.D.
Arch Intern Med. 1960;106(6):859-861. doi:10.1001/archinte.1960.03820060111012.
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The association of multiple cutaneous angiomata and limb hypertrophy as a distinct clinical entity, rather than a coincidental combination of two unrelated anomalies, was first described by Trelat and Monad in 1896. Klippel and Trenaunay subsequently described this rare syndrome as "nevus variqueux osteohypertrophique"; and in a series of papers beginning in 1918, Parkes Weber 1-5 discussed the problem of hemangiectatic hypertrophy of limbs. Since that time a few other case reports of this syndrome have been reported.6-9 However, the apparent rarity of this disorder and the interesting speculative relationship with several other obscure entities, including Maffucci's syndrome, have prompted this report.

Report of a Case  A 16-year-old white youth was admitted for treatment of a chronic leg ulcer which had its origin six months previously following an episode of minor trauma to the right lower leg. The patient gave a history of previous poor healing of wounds incurred

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