0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Causality in Peptic Ulcer

WALTER L. PALMER, M.D.
Arch Intern Med. 1960;106(6):786-796. doi:10.1001/archinte.1960.03820060038003.
Text Size: A A A
Published online

The purpose of this paper is to discuss certain factors considered causal in thepathogenesis of peptic ulcer.

Basic Role of Peptic Digestion  The clinical evidence 1 of the basic role of peptic digestion may be summarized briefly: chronic peptic ulcer occurs only in those portions of the digestive tract exposed to the action of acid gastric juice, and it occurs only in persons whose stomachs secrete acid; its alleged occurrence with persistent achlorhydria is not well documented, although acute and chronic ulcer may occur in patients with low secretory patterns and with transitory achlorhydria. Peptic ulcers invariably heal if the achlorhydria lasts 3 months or longer.2,3The experimental evidence for this concept begins with the demonstration by Claude Bernard 4 that acid gastric juice is able to digest the leg of a living frog. Modern studies date from the demonstration by Williamson and Mann5 in 1923 that transplantation of

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 13

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();