The duration of active immunity varies considerably depending upon the subject, antigen, and method whereby that immunity was induced. In the prevention of tetanus, the physician is frequently hard pressed to decide whether antitoxin or toxoid will be the prophylactic of choice.1 Accordingly, a review of our data concerning the duration of tetanus antitoxin titers was made to attempt to answer this question. For this purpose, a group of adults and children who first received the alcohol-refined toxoids of tetanus and diphtheria was studied.2 The children had not received tetanus toxoid previously, as evidenced by the absence of antitoxin in the initial serum titration. On the other hand, most of the adults had received at least one series of tetanus toxoid injections, either in military service or in civilian medical practice. The annual variation in tetanus antitoxin titers may be noted from an Inspection of Table 1. Subjects
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 11
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.