Introduction Parenteral injection of cyanocobalamin (Vitamin B12) is well established as an effective and reliable treatment for pernicious anemia. In contrast, currently available preparations for oral use have proved to be much less dependable.1 A study was initiated in 1950 in the hematology clinic of The Johns Hopkins Hospital to determine whether relatively large amounts of pure cyanocobalamin, when administered orally without intrinsic factor or other adjuvants, would provide adequate therapy for patients with pernicious anemia. The early results of this investigation2-4 as well as those obtained in other clinics 5-11 were favorable. This paper provides further observations on a group of patients receiving various doses of orally administered cyanocobalamin for periods of up to six and one-half years.
Materials and Methods The diagnosis of pernicious anemia had been well established by clinical and hematological criteria in each patient chosen to participate in this study. In many
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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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