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Comparative Clinical Effectiveness and Toxicity of Vancomycin, Ristocetin, and Kanamycin

BURTON A. WAISBREN, M.S., M.D.; LEONARD KLEINERMAN, M.D.; JOSEPH SKEMP, M.D.; GLENN BRATCHER, B.S.
Arch Intern Med. 1960;106(2):179-193. doi:10.1001/archinte.1960.03820020019005.
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Patients with severe staphylococcal infections that have not responded to the usual antimicrobial therapy are common in present-day hospital practice. It is hoped that the data to be presented regarding the relative efficacy and toxicity of ristocetin, vancomycin, and kanamycin will help the clinician to make a decision about further antimicrobial therapy for these patients. It was possible to alternate the use of ristocetin, vancomycin, and kanamycin in a group of seriously ill patients because the three drugs were discovered within such a short time of each other that no one of them had an opportunity to be established as "the drug of choice" in severe staphylococcic infections.1-3 Each of these three antibiotics acted as a control for the others in the study, and this circumvented the necessity of extrapolating opinions regarding their effectiveness in severe infections from actual experience with milder, non-life-threatening infections.

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Drugs.  —Ristocetin

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