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A Decade of Anti-Inflammatory Steroids from Cortisone to Dexamethasone.

Harold P. Schedl, M.D., Ph.D.
AMA Arch Intern Med. 1960;105(5):823-824. doi:10.1001/archinte.1960.00270170161030.
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Ten years ago, shortly after the introduction of cortisone into clinical medicine, the New York Academy of Sciences held a conference on "The Adrenal Cortex." The total of four publications in this field by the Academy during the past decade are evidence for the intensive research being done by academic and industrial laboratories. The other publications are "Hydro-cortisone, Its Newer Analogs," "Aldosterone as Therapeutic Agents" (1955), and "Mechanism of Corticosteroid Action in Disease Processes" (1953).

This book is the record of a conference held in December, 1958. New biochemical, metabolic, and clinical studies are authoritatively presented: Sarett, evolution of anti-inflammatory steroids from cortisone to the current multisubstituted drugs; Oliveto, synthesis; Silber and Tolksdorf, laboratory evaluation; Tomkins, enzymatic metabolism; Petersen, metabolism in man; Liddle, electrolyte metabolism; Frawley, carbohydrate metabolism; Boland and Savage, rheumatoid arthritis; Dameshek, hematology; and many others. It is interesting that the relative half-lives of cortisol, prednisolone, and


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