We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

The Renal Biopsy in Wilson's Disease

AMA Arch Intern Med. 1960;105(5):758-761. doi:10.1001/archinte.1960.00270170096012.
Text Size: A A A
Published online


The most significant biochemical alterations in Wilson's disease are manifested in the metabolism of copper and aminoaciduria. The excessive copper eliminated in the urine, the notable reduction in serum ceruloplasmin, etc., have recently been studied by means of isotopes, and there is still no clear and certain concept as to pathogenesis. Much less verified is the hypothesis which ascribes the initial defect to a deficiency in ceruloplasmin, an inborn metabolic error which gives rise to a defect in the synthesis of this α-globulin—thus promoting a greater absorption of copper by the intestines and subsequent increased excretion of copper in the urine.

Cartwright has not found any correlation between the blood ceruloplasmin levels and the clinical course in Wilson's disease in 39 patients. On the other hand some authors, such as Uzman, suggest that the primary factor in Wilson's disease is the aminoaciduria. In favor of this hypothesis is the fact


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.