Acute Hemolytic Anemia and Hemoglobinuria Complicating Infectious Mononucleosis

AMA Arch Intern Med. 1960;105(1):108-111. doi:10.1001/archinte.1960.00270130124016.
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The association of acquired hemolytic anemia and infectious mononucleosis is undoubtedly rare, there being only 21 cases found in the literature.1-17 The demonstration of autoimmune bodies as the etiological mechanism in the hemolytic process has been well documented in only six cases.3,5,9,10,13,14 The case to be reported was one of infectious mononucleosis complicated by fulminating hemolysis and massive hemoglobinuria in which an autoimmune mechanism was felt to be responsible.

Report of Case  The patient was a 45-year-old man who was in good health until seven days before admission to hospital. At that time, he began to have chills, fever, and nausea, associated with generalized malaise. He remained at home for one week with the above complaints before seeking medical aid. He was admitted to hospital by his physician, who noted slight icterus associated with a dark urine, the provisional diagnosis being infectious hepatitis. There had been no previous


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