We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

The Nephrotic Syndrome Renal Biopsy Findings in Adults Responding to Prednisone

AMA Arch Intern Med. 1959;104(5):684-691. doi:10.1001/archinte.1959.00270110004002.
Text Size: A A A
Published online


Introduction  The value of renal biopsy in the diagnosis and management of the nephrotic syndrome appears well established.1-5 We have observed eight adults with severe nephrotic syndromes who were treated intensively with prednisone. Diuresis to dryness was observed in every case after the initial course of therapy. In order to demonstrate the pathologic lesion which might be anticipated to respond favorably to prednisone, these patients have been studied by renal biopsy. The clinical diagnosis of nephrotic syndrome has been based on the presence of heavy albuminuria, not less than 6.2 gm. per day, edema, and hypoalbuminemia.

Materials and Methods  These eight patients included six males and two females, aged 24 to 41 years. Except for certain special lipid studies, determinations were made by the hospital clinical laboratory. Percutaneous renal biopsy was performed as previously described.6


Clinical Findings (Table 1).  —These patients uniformly displayed a well-developed nephrotic syndrome.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

16 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.