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Radioiodine in the Treatment of Hyperthyroidism:  A Seven-Year Evaluation

SIDNEY RUBENFELD, M.D.; MARTIN LOWENTHAL, M.D.; ANTHONY KOHN, M.D.; NATHAN MITCHELL, M.D.; S. STEVEN BRODIE, Ph.D.
AMA Arch Intern Med. 1959;104(4):532-538. doi:10.1001/archinte.1959.00270100018004.
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It is the purpose of this presentation to add a seven-year experience to the evergrowing literature of the treatment of hyperthyroidism with radioactive iodine. This experience with 294 consecutive patients has led to the formation of some opinions concerning several controversial aspects, such as minimum age for treatment, size of dose and dosage schedules, and effects of supplementary antithyroid drugs.

Material and Methods  A total of 294 patients (237 females and 57 males) with hyperthyroidism, from the Radioisotope Service of the Jewish Memorial Hospital, New York, and from our private files over the past seven years constitute the basis of this report. The diagnosis of hyperthyroidism was established by a complete history, physical examination, and an I131 thyroid profile.1 The thyroid profile consists of a 24-hour uptake, conversion ratio, and measurement of the radioactivity of the saliva. In many instances a basal metabolic rate, chemical protein-bound iodine, and

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