Between September, 1945, and June, 1957, four hundred thirty-one patients with hyperthyroidism were treated with radioiodine at the University of California Medical Center. Although other large series of radioiodine-treated patients have been recorded,1-3 certain features regarding patient selection, duration of follow-up of the initial group of patients, incidence and time of hypothyroidism, and effect on exophthalmos suggested the present analysis.
All patients with hyperthyroidism in whom definitive therapy with radioiodine was initiated between September, 1945, and June, 1957, are included in this study. Although at first patients with nodular goiter were not treated, after November, 1948, these have been accepted if a reasonably strong contraindication to thyroidectomy was present. Previous to 1953, patients of all ages were treated; patients under 40 years of age were treated since that time, however, only if there was a postsurgical recurrence or some factor contraindicating surgery or other form of therapy. Pregnancy or