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Staphylococcal Septicemia:  Report of a Case with Hyponatremia and Eventual Recovery Through Use of Multiple Antibiotics and Adrenal Steroids

WILLIAM PAULE, MC; NICHOLAS F. CONTE, MC
AMA Arch Intern Med. 1959;103(5):796-798. doi:10.1001/archinte.1959.00270050118018.
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Introduction  Staphylococcal septicemia represents a major problem in therapy despite the availability of numerous antibiotics. Mortality remains high,1,2,5 and the course of the disease may be very prolonged.1,3 The staphylococcus exhibits remarkable ease in developing resistance to antibiotics,1-5 and for this reason it has become common practice to judge therapy with in vitro sensitivity studies, thereby leading to the use of multiple antibiotic agents concomitantly.

Report of Case  A 17-year-old white soldier entered the hospital April 6, 1957, with sudden onset of anterior chest pain; three days earlier he developed dysphagia and nonproductive cough followed by headache, chills, fever, and retrosternal discomfort. The past history and family history were irrelevant.On admission the physical examination disclosed an asthenic youth, moderately ill but oriented, with temperature of 104 F, mild tachycardia, and tachypnea. The oropharynx was mildly injected; splinting of the right hemithorax, diminished breath sounds, minimal dullness

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