We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Bone Changes in Neurofibromatosis Report of a Case with Coincidental Osteitis Deformans and Review of the Literature

AMA Arch Intern Med. 1959;103(4):570-580. doi:10.1001/archinte.1959.00270040056006.
Text Size: A A A
Published online


Introduction  Even before von Recklinghausen's original monograph, in 1882,1 the literature has contained references to various bone changes complicating neurofibromatosis, e. g., bowing and pseudarthroses,2 disorders of growth.3 Indeed, Wilson4 includes bone affection in his definition of the syndrome, and Saville et al.5 state that neurofibromatosis is characterized by lesions of skin, nerve, and bone.Diverse secondary features other than bony which are said to occur can be grouped into psychological and endocrine. Regarding the former, perhaps the most pertinent comment is made by Wilson,4 "that some sufferers from a disease marked by unsightly deformities and disfigurements, especially when the face is concerned, should become sensitive, despondent or misanthropic need occasion no surprise." Authors further reflect that of diverse psychical disorders reported in connection with the malady none is specific and most are purely incidental.Various investigators, including Preiser and Davenport 6 and Yakovlev and Guthrie,7 have reported an increased


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.