Studies of Proteolytic Enzymes in Cerebrospinal Fluid:  Capacity of Incubated Mixtures of Cerebrospinal Fluid and Plasma Proteins to Form Vasodilator Substances That Contract the Isolated Rat Uterus

AMA Arch Intern Med. 1959;103(1):86-94. doi:10.1001/archinte.1959.00270010092012.
Text Size: A A A
Published online

A study of tissue fluid removed from regions of local tenderness in the scalp during vascular headache of the migraine type indicated that this fluid contained a painthreshold-lowering substance.4,15 It had many of the properties of vasodilator polypeptides derived from plasma proteins. Armstrong et al.2,3 demonstrated that such polypeptides were present in blister fluid, in fluid collected from painful joints, and in inflammatory pleural fluid. At about the same time, Hilton and Lewis11 described a proteolytic enzyme present in saliva and in saline perfusate of the salivary gland. This enzyme formed vasodilator polypeptides when incubated with plasma proteins. Increased amounts of enzyme were observed during heightened metabolic activity of the gland. Hilton and Lewis concluded that the enzyme and polypeptide are responsible for local vasomotor control in the salivary gland. The properties of the polypeptide correspond closely to those of "bradykinin," the name given by Rocha e


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 41

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.