0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Aldosterone Antagonists

GRANT W. LIDDLE, M.D.
AMA Arch Intern Med. 1958;102(6):998-1004. doi:10.1001/archinte.1958.00260230144018.
Text Size: A A A
Published online

For 30 years it has been known that steroidal hormones of the adrenal cortex tend to promote sodium conservation by the kidneys. It is now believed that the most potent sodium-retaining hormone of the adrenal cortex is aldosterone.

It has been shown repeatedly that the ability of normal persons to conserve sodium in the face of sodium deprivation is dependent upon the secretion of relatively large quantities of aldosterone by the adrenals.1,2 Lack of ability to secrete aldosterone in the face of sodium deprivation explains the serious renal sodium wasting which is characteristic of patients with untreated Addison's disease. It has also been shown that the common disorders of the circulation which are accompanied by maximal tubular reabsorption of sodium and edema formation (e. g., cirrhosis, nephrosis, and congestive heart failure) are associated with increased secretion of aldosterone.

For the sake of perspective it should be emphasized that aldosterone

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();