Treatment of the Deep Mycoses

AMA Arch Intern Med. 1958;101(4):765-802. doi:10.1001/archinte.1958.00260160089013.
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Introduction  Histoplasmosis, blastomycosis, coccidioidomycosis, actinomycosis, nocardiosis, cryptococcosis, moniliasis, aspergillosis, sporotrichosis, geotrichosis, and mucormycosis comprise the deep mycotic infections. During the past 10 years significant advances in knowledge concerning their epidemiology, pathogenesis, and treatment have been made. These fungal infections manifest a variety of signs and symptoms, often indistinguishable from those caused by viruses, bacteria, and parasites. The pathogenic fungi should be considered in the differential etiology of both acute and chronic pulmonary infections, skin and mucous membrane lesions, and infections of the brain and blood.Once suspected, fungal infections can often be readily verified by identification of the organism by culture or direct examination of exudates and biopsy material. The pathogenic fungi are not fastidious and will grow on enriched blood agar and a variety of the more restricted media. Thus, failure to make an early diagnosis in most cases is due to the fact that the physician does not


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