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Primary Reticulum-Cell Sarcoma of the Leptomeninges

AMA Arch Intern Med. 1958;101(2):333-338. doi:10.1001/archinte.1958.00260140165025.
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Earlier authors frequently described any rapidly growing, highly cellular intracranial tumor as a "sarcoma." Inadequate clinical and microscopic descriptions, doubtful photomicrographs, the failure to make proper use of special stains, incomplete postmortem examinations, and, especially, the use of multiple synonyms for the same type of tumor makes it very difficult to review the pertinent literature on this subject. More recent discussions are in agreement on one point, however, which is that if one restricts the use of the term "sarcoma" to malignant mesodermal tumors they are very uncommon indeed intracranially. Thus, they made up only 0.7% of 2023 brain tumors in Cushing's1 series and less than 1% of Olivecrona's 2 even larger series of 4188 cerebral neoplasms.

True cerebral sarcomas occur usually as focal tumor masses (isolated or multiple) with or without local involvement of the overlying meninges. They may also begin in the periadventitial tissue of the lepto


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