Vitamin K Deficiency Associated with Prolonged Antibiotic Administration

AMA Arch Intern Med. 1957;100(6):986-988. doi:10.1001/archinte.1957.00260120130015.
Text Size: A A A
Published online

Vitamin K deficiency as the cause of a hemorrhagic diathesis has been recognized for many years. Clinical deficiency of this vitamin has usually been associated with some defect in absorption from the gastrointestinal tract, such as that associated with biliary-tract obstruction or with sprue. Dietary deficiency of vitamin K has not been important because of the ability of the normal intestinal bacteria to synthesize vitamin K. Since the introduction of the broadspectrum antibiotics it has become possible to greatly reduce the bacterial content of the intestine and, as a consequence, to decrease the amount of vitamin K produced. The fact that this can occasionally produce a severe hemorrhagic diathesis is attested by the following case.

Report of Case  A 46-year-old white woman was admitted to the urology service of the Medical College of Virginia Hospital on June 6, 1956, because of right ureteral obstruction and chronic renal infection. Five years


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.