We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Purpura Hyperglobulinemica Terminating in Multiple Myeloma

AMA Arch Intern Med. 1957;100(3):478-483. doi:10.1001/archinte.1957.00260090134019.
Text Size: A A A
Published online


In 1943, Waldenström delineated a syndrome consisting of recurring petechial eruption of the lower half of the body and hyperglobulinemia persisting for many years, apparently harmlessly.1 Other authors have confirmed the existence and the benignancy of this syndrome, although its pathogenesis has remained obscure. Of the 19 reported cases known to us, some have been associated with one of a variety of chronic inflammatory diseases, while in other cases no significant concomitant disease was apparent.2-5

A possible relationship to multiple myeloma has been suggested by the presence in purpura hyperglobulinemica of similar serum protein abnormalities and, frequently, of marrow lymphocytosis and anemia. The case presently reported is the first in which this possible relationship has evidently materialized, and it serves to emphasize that purpura hyperglobulinemica, even of over 10 years' duration, is not always benign.

Report of Case  A white male hydraulic engineer, born in 1901, was first


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

20 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.