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ARTICLE |

Experimental Methods for the Evaluation of Drugs in Various Disease States.

William B. Bean, M.D.
AMA Arch Intern Med. 1957;100(2):338-339. doi:10.1001/archinte.1957.00260080164042.
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ABSTRACT

One hundred fifty years ago the value of a drug was likely to be judged by what some authority had written of it in a textbook. This had been copied from another book. Therapeutic nihilism arose from such a vacuum. During recent decades clinical investigation has had as one of its major obsessions the evaluation of drugs in therapy. At the point where physiology, pharmacology, chemistry, and clinical medicine meet, we find the patient. He is the ultimate subject and object in all medical investigation, since the final aim in biology is the understanding of man in health and disease. The mathematicians, the statisticians, the single blindfolders, the double blindfolders, the sophisticated, and the novice have poured out a vast plethora of reports about drug tests. But in spite of this there are more drugs and many more names for drugs than we know what to do with. The reasons

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